Microdialysis相关论文
Objective:To quantify the purine concentrations of the acupoints along the pericardium and nonpericardium meridians unde......
Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal i
Aim: To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult ......
To evaluate the influence of diabetes on the permeation of dexamethasone acetate(DA) and dexamethansone sodium phosphate......
Possible involvement of amino acids in the central regulation of cardiovascular responses in conscio
The paraventricular nuclues of the hypothalamus (PVN) is a central site for the integration of the neuroendocrine system......
The aim of this study was to evaluate the influence of diabetes on the percataneous permeation and absorption of dexamet......
Oxytocin receptor involved in the inhibition of oxytocin on methamphetamine-induced glutamate releas
Objective Recent studies showed that the oxytocin (OT),a neurohypophyseal neuropeptide which affected adaptive central n......
In vitro/in vivo transdermal delivery study of NLCs loaded with the alkaloidal extract from Aconitum
The aims of the present study were to evaluate the microstructure and study the in vitro/in vivo transdermal delivery of......
Aim: To study the plasma protein binding rate of puerarin.Methods: The microdialysis-HPLC method was applied to determin......
A modified LC-MS/MS method for determination of tetramethylpyrazine in microdialysis samples and cal
Tetramethylpyrazine (TMP) is one of the most important active ingredients of a Chinese herb Ligusticum wallichii Francha......
Electro-responsive nanoparticles improve antiepileptic effect of phenytoin in generalized tonic-clon
OBJECTIVE Previously we developed electro-responsive hydrogel nanoparticles(ERHNPs)modified with angiopep-2(ANG)to facil......
Antiepileptic effect of uridine may be caused by regulating dopamine release and receptor expression
Uridine is a potential endogenous neuromodulator studied for several decades for its antiepileptic effect,but the result......
Characteristics and pharmacokinetics of tripterygium glycosides nano-carries transdermal delivery sy
The traditional Chinese medicine tripterygium glycosides (TPG) is used clinically to treat some Rheumatism, Eczema, immu......
Platelet activating factor mediates blood brain barrier dysfunction through up-regulation of MMP-9 i
Platelet-activating factor (PAF) was a lipid mediator that aggravated brain injury after cerebral ischemia and reperfusi......
Preparation of paeonol transdermal delivery systems based on the microemulsion-based gels and the ch
Objectives:To investigate the pharmacokinetics of paeonol microemulsion,microemulsion-based gels and marketed paeonol oi......
目的:研究利用体外模拟方式测定阿魏酸微透析血液探针回收率的方法 及影响因素。方法:HPLC法测定阿魏酸的含量；回收率的测定采用增......
Microdialysis-based-HPLC determinates norepinephrine release from cardiac sympathetic nerves in mamm
Sympathetic nerve in heart is essential in heart physiology and diseases, because sympathetic nerve release catecholamin......
The Percutaneous Permeability and Absorption of Dexamethasone Esters in diabetic rats: a preliminary
To evaluate the influence of diabetes on the permeation of dexamethasone acetate(DA) and dexamethansone sodium phosphate......
Effect of KA and NMDA lesion of the medial prefrontal cortex and dorsal hippocampus on the methamphe
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Histaminergic output from the tuberomammillary nucleus (TMN) is considered to play a crucial role in mediating arousal.U......
Objective:To obsreve the effect of Storax on the brain and blood concentration of sulpiride in rats and to explore the p......
Analysis of pesticide residuals in tea water samples by hollow fiber liquid-phase microextraction an
Microdialysis sampling was investigated as a liquid-phase microextraction in the analysis of pesticide residual in tea w......
Quantitative analysis of 1-naphthylamine in aqueous samples by microdialysis pretreatment and high p
Traditionally, quantitative measurement of trace chemicals requires a variety of pretreatment methods to enrich target a......
ObjectiveTo observe the effect of hypothermia on amino acid release in ischemic side of brain in gerbils.Methods18 male ......
Effect of Shen-Fu Injection Pretreatment to Myocardial Metabolism During Untreated Ventricular Fibri
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微透析是一种新型的采样技术，可快速、连续地对目标位置进行取样，近年来广泛应用于体液采集，特别是针对难以直接获取样品部位，如颅内、......
ECO-FRIENDLY ANALYSIS OF PHENOXY ACIDIC HERBICIDES BY A MICRODIALYSIS EXTRACTION DEVICE COUPLED SUBC
A eco-friend analytical method by using a microdialysis extraction device coupled sub-critical water ion-pair liquid......
The characteristics and pharmacokinetics of tripterygium glycosides nano-carries transdermal deliver
The traditional Chinese medicine Tripterygium glycosides(TPG)is used clinically to treat some Rheumatism,Eczema,immu......
Effect of stimulating the acupoints Feishu (BL 13) and Dazhui (GV 14) on transdermal uptake of sinap
OBJECTIVE:To investigate the effect of stimulating the acupoints Feishu (BL 13) and Dazhui (GV 14) on the transdermal up......
Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo con
Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target......
目的探讨两种供氧方式对于全脑缺血-再灌注模型脑内羟自由基水平影响。方法雄性长爪沙鼠16只，脑立体定位于右侧海马CA1区植入微透析......
Objective To investigate the prevention effects and the physicochemical mechanisms of action of Tong Qiao Huo Xue Tang o......
Dynamic Study of the Effect of Electroacupuncture on Dopamine in the Striatum for Rats with Cerebral
目的:观察脑缺血再灌注模型大鼠纹状体内多巴胺的动态变化,以及电针对该变化的影响.方法:运用微透析采样技术、高效液相检测技术,......
目的探讨左旋多巴在大鼠血液和纹状体细胞外液药物浓度随时间变化规律。方法大鼠单次灌胃给予左旋多巴48mg.kg-1和苄丝肼12 mg.kg-......
目的考察低相对分子质量肝素凝胶经皮给药后大鼠皮肤和血液中低分子量肝素含量,评价其透皮药动学特征。方法SD大鼠腹部脱毛后经皮......
探讨不同剂量组的补阳还五汤益气组与活血组有效成分在MCAO大鼠体内的药动学特征.复制大鼠脑缺血再灌注动物模型,建立补阳还五汤微......
目的:考察醋酸曲安奈德微透析探针体外回收率的影响因素,探索提高微透析探针回收率的方法。方法:采用高效液相色谱法考察温度、灌......
目的:建立液质联用(LC-MS/MS)法同时测定大鼠脑透析液中谷氨酸、γ氨基丁酸、天冬氨酸、甘氨酸、谷氨酰胺和牛磺酸等6种氨基酸的含......
目的 采用微透析技术研究虎杖苷的体外血浆蛋白结合率,并与超滤法比较.方法 微透析探针依次浸入含虎杖苷20,60,200 μg·mL-1的大......
目的对18α-GL固体脂质纳米粒(18α-GL-SLN)的药动学进行研究。方法在大鼠股静脉和肝脏同时植入探针,尾静脉给药后,同步微透析采样......
目的研究大鼠腹腔注射盐酸川芎嗪后川芎嗪在血、脑中的药动学差异,并比较两个剂量给药后的药动学参数。方法以川芎嗪为检测药物,HP......
目的 研究天麻素在大鼠十二指肠给药后的脑药动学和不同脑区的分布.方法 将大鼠麻醉后,通过其十二指肠给天麻素,剂量为200 mg·kg-......
,Ischemic preconditioning protects post-ischemic renal function in anesthetized dogs: role of adenos
Aim: To investigate the effects of renal ischemic preconditioning (IPC) on both renal hemodynamics and the renal interst......
,Orexin A promotes histamine, but not norepinephrine or serotonin, release in frontal cortex of mice
Aim: To investigate the effects of orexin A on release of histamine, norepinephrine, and serotonin in the frontal cortex......
Liver metabolism is commonly considered the major determinant in drug discovery and development. Many in vitro drug meta......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
Chronic deep brain stimulation of the subthalamic nucleus in a monkey model of hemiparkinsonian Dyna
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微透析技术（MD）是一种在不破坏机体内环境的前提下，对生物体细胞间液内源性或外源性物质进行连续取样和分析的微量生化取样技术。MD ......
Effect of mild hypothermia on glucose metabolism and glycerol of brain tissue in patients with sever
Objective:To study the effect of mild hypothermia on glucose metabolism and glycerol of brain tissue in patients with se......
